Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 5/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.53 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860392 | 0.91 | PAX8 (0.58) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860400 | 0.90 | PAX8 (0.56) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860357 | 0.89 | PAX8 (0.56) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860358 | 0.88 | PAX8 (0.65) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860317 | 0.85 | PAX8 (0.64) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL16980371 | 0.85 | PAX8 (0.62) | PAX8CASP6PLCG1PLCB3KDM4E | |
| SCHEMBL17860363 | 0.85 | PAX8 (0.68) | PAX8CASP6PLCG1PLCB3KDM4E | |
| SCHEMBL17860385 | 0.84 | PAX8 (0.57) | PAX8CASP6PLCG1PLCB3KDM4E | |
| SCHEMBL17860426 | 0.84 | PAX8 (0.52) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860453 | 0.84 | PAX8 (0.73) | PAX8CASP6PLCG1PLCB3GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |