Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 8/20 | 0.57 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.53 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860302 | 0.92 | PAX8 (0.55) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860363 | 0.89 | PAX8 (0.68) | PAX8CASP6PLCG1PLCB3RAB9A | |
| SCHEMBL17860358 | 0.87 | PAX8 (0.65) | PAX8CASP6PLCG1PLCB3MEN1 | |
| SCHEMBL17860386 | 0.86 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3RAB9A | |
| SCHEMBL17860317 | 0.85 | PAX8 (0.64) | PAX8CASP6PLCG1PLCB3RAB9A | |
| SCHEMBL16980371 | 0.85 | PAX8 (0.62) | PAX8CASP6PLCG1PLCB3KDM4E | |
| SCHEMBL17860297 | 0.85 | PAX8 (0.72) | PAX8CASP6PLCG1PLCB3RAB9A | |
| SCHEMBL17860392 | 0.85 | PAX8 (0.58) | PAX8CASP6PLCG1PLCB3RAB9A | |
| SCHEMBL17860390 | 0.84 | PAX8 (0.58) | PAX8CASP6PLCG1PLCB3KDM4E | |
| SCHEMBL17860400 | 0.84 | PAX8 (0.56) | PAX8CASP6PLCG1PLCB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |