Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 6/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.46 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860386 | 0.92 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860438 | 0.92 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860439 | 0.92 | PAX8 (0.55) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860304 | 0.91 | PAX8 (0.49) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860513 | 0.91 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3ALDH1A1 | |
| SCHEMBL17860425 | 0.91 | PAX8 (0.49) | PAX8CASP6PLCG1PLCB3KDM4E | |
| SCHEMBL17860422 | 0.90 | PAX8 (0.49) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860357 | 0.89 | PAX8 (0.56) | PAX8CASP6PLCG1PLCB3TSHR | |
| SCHEMBL17860451 | 0.88 | PAX8 (0.47) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860426 | 0.87 | PAX8 (0.52) | PAX8CASP6PLCG1PLCB3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |