Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 4/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | PLCG1 | P19174 | 4/20 | 0.46 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860386 | 0.93 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3ALDH1A1 | |
| SCHEMBL17860451 | 0.92 | PAX8 (0.47) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860439 | 0.92 | PAX8 (0.55) | PAX8CASP6PLCG1PLCB3LMNA | |
| SCHEMBL17860438 | 0.92 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860513 | 0.91 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3ALDH1A1 | |
| SCHEMBL17860423 | 0.91 | PAX8 (0.51) | PAX8CASP6PLCG1PLCB3ALDH1A1 | |
| SCHEMBL17860304 | 0.90 | PAX8 (0.49) | PAX8CASP6PLCG1PLCB3 | |
| SCHEMBL17860422 | 0.90 | PAX8 (0.49) | PAX8CASP6PLCG1PLCB3MCHR1 | |
| SCHEMBL17860357 | 0.87 | PAX8 (0.56) | PAX8CASP6PLCG1PLCB3LMNA | |
| SCHEMBL17860426 | 0.86 | PAX8 (0.52) | PAX8CASP6PLCG1PLCB3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |