Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 10/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.50 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29472215 | 0.95 | FTO (0.55) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL16544 | 0.95 | FTO (0.55) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL9013831 | 0.94 | FTO (0.54) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL10486825 | 0.94 | FTO (0.54) | FTOMAPTHPGDMEN1HTT | |
| Hydrochloric Acid SCHEMBL5440613 | 0.94 | FTO (0.54) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL3484938 | 0.90 | FTO (0.43) | FTOMAPTHPGDMEN1HTT | |
| Hexaethylene Glycol SCHEMBL5438588 | 0.89 | FTO (0.46) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL136169 | 0.85 | FTO (0.56) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL7517620 | 0.83 | MEN1 (0.38) | FTOMAPTHPGDMEN1HTT | |
| SCHEMBL5664537 | 0.83 | FTO (0.51) | FTOMAPTHPGDMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180209966-A1 | FLUORESCENCE POLARIZATION IMMUNOASSAY METHOD FOR DETECTING CARBARYL | OILCROPS RESEARCH INSTITUTE OF CHINESE ACADAMY OF AGRICULTURE SCIENCES (CN) | 2018-07-26 | — | — | US | claimed |
| CN-110382533-B | Antibodies that specifically bind CD66c and uses thereof | 锦湖HT株式会社 | 2023-09-22 | — | — | CN | disclosed |
| US-10406243-B2 | Methods of treatment comprising a polyrotaxane and medicinal composition | NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) | 2019-09-10 | — | — | US | disclosed |
| EP-3037097-B1 | POLYROTAXANE AND MEDICINAL COMPOSITION | UNIV NAT CORP TOKYO MEDICAL & DENTAL (JP) | 2018-09-19 | — | — | EP | disclosed |
| US-20180209966-A1 | FLUORESCENCE POLARIZATION IMMUNOASSAY METHOD FOR DETECTING CARBARYL | OILCROPS RESEARCH INSTITUTE OF CHINESE ACADAMY OF AGRICULTURE SCIENCES (CN) | 2018-07-26 | — | — | US | disclosed |
| US-20160199512-A1 | POLYROTAXANE AND MEDICINAL COMPOSITION | NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY (JP) | 2016-07-14 | — | — | US | disclosed |
| EP-3037097-A1 | POLYROTAXANE AND MEDICINAL COMPOSITION | National University Corporation Tokyo Medical and Dental University (JP) | 2016-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10406243-B2 | Methods of treatment comprising a polyrotaxane and medicinal composition | BECN1, LDLR, NPC1 | FTO 4685/4885MAPT 770/4885HPGD 2428/4885 |
| US-20160199512-A1 | POLYROTAXANE AND MEDICINAL COMPOSITION | LDLR, BECN1, TFEB | FTO 4616/4885MAPT 1243/4885HPGD 2174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.