Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 3/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 3/20 | 0.40 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | TET3 | O43151 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.40 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.40 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14875882 | 0.87 | HSP90AA1 (0.42) | KDM4EALDH1A1HSP90AA1KDM5BSMN1; SMN2 | |
| SCHEMBL14882786 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1HSP90AA1ASPHKDM8 | |
| SCHEMBL27966141 | 0.82 | HSP90AA1 (0.44) | KDM4EALDH1A1HSP90AA1KDM4AKDM5C | |
| SCHEMBL3182720 | 0.78 | HSP90AA1 (0.66) | HSP90AA1SMN1; SMN2HPGDTSHRHSD17B10 | |
| SCHEMBL4431981 | 0.77 | HSP90AA1 (0.51) | ALDH1A1HSP90AA1MAPTSMN1; SMN2LMNA | |
| SCHEMBL28097350 | 0.74 | HSP90AA1 (0.39) | KDM4EALDH1A1HSP90AA1SMN1; SMN2NAMPT | |
| SCHEMBL14876258 | 0.73 | NAMPT (0.44) | KDM4EALDH1A1HSP90AA1ALKBH5FTO | |
| SCHEMBL14876080 | 0.73 | NAMPT (0.44) | KDM4EALDH1A1HSP90AA1KDM5BSMN1; SMN2 | |
| SCHEMBL18135114 | 0.73 | NAMPT (0.44) | KDM4EALDH1A1HSP90AA1ALKBH5FTO | |
| SCHEMBL14876436 | 0.72 | KDM4E (0.62) | KDM4EALDH1A1ASPHKDM8ALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794616-B1 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | disclosed |