Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.37 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.37 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865959 | 0.89 | METTL3 (0.38) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL17865958 | 0.88 | TP53 (0.45) | METTL3METTL14RXFP1NAE1CA2 | |
| SCHEMBL17865921 | 0.87 | METTL3 (0.54) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL17865977 | 0.85 | NAE1 (0.43) | METTL3METTL14PPARGRXFP1NR2E3 | |
| SCHEMBL17865976 | 0.84 | CCNA2 (0.44) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL17866047 | 0.84 | PPARG (0.42) | METTL3METTL14PPARGRXFP1NR2E3 | |
| SCHEMBL17865956 | 0.82 | NAE1 (0.43) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL17865924 | 0.82 | UBA6 (0.38) | METTL3METTL14NAE1CA2GRK5 | |
| SCHEMBL17866004 | 0.82 | AURKA (0.42) | NAE1CA2GRK5CSNK1A1UBA6 | |
| SCHEMBL191932 | 0.82 | NAE1 (0.57) | NAE1CA2GRK5CSNK1A1UBA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |