Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113765 | 0.87 | LMNA (0.50) | CNR1MAPTSMN1; SMN2NPSR1POLB | |
| SCHEMBL17866254 | 0.84 | MAPT (0.49) | CNR1MAPTSMN1; SMN2NPSR1POLB | |
| SCHEMBL17866272 | 0.83 | MAPT (0.46) | CNR1MAPTSMN1; SMN2NPSR1POLB | |
| SCHEMBL17866267 | 0.83 | CNR1 (0.44) | CNR1MAPTSMN1; SMN2NPSR1PTGS2 | |
| SCHEMBL17866289 | 0.81 | MAPT (0.45) | CNR1MAPTSMN1; SMN2NPSR1PTGS2 | |
| SCHEMBL17866255 | 0.80 | CNR1 (0.46) | CNR1MAPTSMN1; SMN2NPSR1PTGS2 | |
| SCHEMBL17866260 | 0.80 | CNR1 (0.44) | CNR1MAPTSMN1; SMN2NPSR1PTGS2 | |
| SCHEMBL17866273 | 0.80 | CNR1 (0.44) | CNR1MAPTSMN1; SMN2NPSR1PTGS2 | |
| SCHEMBL17866274 | 0.80 | CNR1 (0.44) | CNR1MAPTSMN1; SMN2NPSR1LMNA | |
| SCHEMBL17866275 | 0.80 | CNR1 (0.45) | CNR1MAPTSMN1; SMN2NPSR1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627637-B1 | N-PYRIDIN-3-YL OR N-PYRAZIN-2-YL CARBOXAMIDES | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | claimed |