Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 5/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142075 | 0.92 | PLA2G2A (0.46) | CACNA1HCREBBPPLA2G2APTGS2KDM4E | |
| SCHEMBL109314 | 0.84 | CACNA1H (0.42) | CACNA1HPLA2G2AGAAMAPTKMT2A | |
| SCHEMBL170380 | 0.84 | PDE1B (0.41) | CACNA1HCREBBPJAK2 | |
| SCHEMBL143205 | 0.78 | PLA2G2A (0.49) | PLA2G2AKDM4EALDH1A1GLAGAA | |
| SCHEMBL141523 | 0.76 | PLA2G2A (0.47) | PLA2G2AKDM4EALDH1A1JAK2MAPT | |
| SCHEMBL144259 | 0.72 | JAK2 (0.42) | PLA2G2AKDM4EALDH1A1GAAJAK2 | |
| SCHEMBL144258 | 0.72 | HDAC1 (0.37) | PLA2G2AKDM4EALDH1A1GLAGAA | |
| SCHEMBL143937 | 0.71 | PPARG (0.44) | PLA2G2AKDM4EALDH1A1GLAGAA | |
| SCHEMBL13284186 | 0.71 | PPARG (0.44) | PLA2G2APTGS2KDM4EALDH1A1GLA | |
| SCHEMBL143786 | 0.71 | JAK2 (0.52) | PLA2G2AALDH1A1GLAHPGDCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058988-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | JAK2, JAK1, JAK3 | CACNA1H 4219/4885CREBBP 1087/4885PLA2G2A 4509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.