Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL110219 | 0.95 | P2RX3 (0.39) | PPARGGAAHPGDP2RX3CA12 | |
| SCHEMBL143937 | 0.95 | PPARG (0.44) | PPARGGRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL139706 | 0.83 | JAK2 (0.38) | PPARGGRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL110216 | 0.76 | JAK2 (0.39) | ALDH1A1P2RX3 | |
| SCHEMBL141523 | 0.74 | PLA2G2A (0.47) | KDM4EALDH1A1P2RX3PLA2G2A | |
| SCHEMBL143205 | 0.73 | PLA2G2A (0.49) | KDM4EALDH1A1GLAGAAHPGD | |
| SCHEMBL142075 | 0.71 | PLA2G2A (0.46) | PTGS2KDM4EALDH1A1GLAGAA | |
| SCHEMBL144379 | 0.71 | JAK2 (0.51) | KDM4EALDH1A1GAAHPGDCA12 | |
| SCHEMBL178706 | 0.71 | CACNA1H (0.44) | PPARGPTGS2KDM4EALDH1A1GLA | |
| SCHEMBL110879 | 0.70 | PLA2G2A (0.53) | MAPK8PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |