Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17870863 | 1.00 | PIK3CD (0.42) | PIK3CDLMNACHRM2CHRM4CHRM1 | |
| SCHEMBL6520807 | 0.83 | LMNA (0.41) | PIK3CDLMNAGAAALDH1A1KDM4E | |
| SCHEMBL6525034 | 0.83 | LMNA (0.41) | PIK3CDLMNAGAAALDH1A1KDM4E | |
| SCHEMBL19747069 | 0.82 | MEN1 (0.44) | LMNACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL17870853 | 0.82 | MEN1 (0.44) | LMNACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5545260 | 0.79 | TNKS (0.44) | CHRM2CHRM4CHRM1CHRM3GAA | |
| SCHEMBL5545264 | 0.79 | TNKS (0.44) | CHRM2CHRM4CHRM1CHRM3GAA | |
| SCHEMBL4181530 | 0.77 | CA12 (0.40) | LMNACHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4185898 | 0.76 | MAPT (0.40) | LMNAGAAALDH1A1KDM4E | |
| SCHEMBL6516899 | 0.74 | LMNA (0.45) | PIK3CDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237424-A1 | PROCESS OF MAKING CENICRIVIROC AND RELATED ANALOGS | Tobira Therapeutics, Inc. (US) | 2017-11-01 | — | — | EP | claimed |
| WO-2016105527-A1 | PROCESS OF MAKING CENICRIVIROC AND RELATED ANALOGS | TOBIRA THERAPEUTICS, INC. (US) | 2016-06-30 | — | — | WO | claimed |
| EP-3237424-A1 | PROCESS OF MAKING CENICRIVIROC AND RELATED ANALOGS | Tobira Therapeutics, Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016105527-A1 | PROCESS OF MAKING CENICRIVIROC AND RELATED ANALOGS | TOBIRA THERAPEUTICS, INC. (US) | 2016-06-30 | — | — | WO | disclosed |