Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30054156 | 1.00 | RIPK1 (0.53) | RIPK1SIGMAR1LMNAADORA3BRD4 | |
| SCHEMBL17870940 | 1.00 | RIPK1 (0.53) | RIPK1SIGMAR1LMNAADORA3BRD4 | |
| SCHEMBL25017953 | 0.82 | CHRM2 (0.57) | RIPK1LMNAADORA3TSHRKMT2A | |
| SCHEMBL23562447 | 0.82 | CHRM2 (0.50) | RIPK1KMT2ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28497094 | 0.80 | RIPK1 (0.49) | RIPK1SIGMAR1LMNAKMT2AALDH1A1 | |
| SCHEMBL19471162 | 0.79 | RIPK1 (0.43) | RIPK1SIGMAR1LMNAKMT2AALDH1A1 | |
| SCHEMBL17870947 | 0.79 | RIPK1 (0.43) | RIPK1SIGMAR1LMNAKMT2AALDH1A1 | |
| SCHEMBL19471071 | 0.77 | CHRM2 (0.46) | RIPK1SIGMAR1BRD4TSHRKMT2A | |
| SCHEMBL17870932 | 0.77 | CHRM2 (0.46) | RIPK1SIGMAR1BRD4TSHRKMT2A | |
| SCHEMBL17870936 | 0.77 | RIPK1 (0.49) | RIPK1LMNABRD4TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107108492-B | Cell necrosis inhibitor | 北京生命科学研究所 | 2021-03-19 | — | — | CN | disclosed |
| EP-3224245-B1 | NECROSIS INHIBITORS | NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) | 2018-09-12 | — | — | EP | disclosed |
| EP-3224245-A1 | NECROSIS INHIBITORS | National Institute Of Biological Sciences, Beijing (CN) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016101887-A1 | NECROSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2016-06-30 | — | — | WO | disclosed |