Sugi Predict

Sugi Predict / Compounds / SCHEMBL17870947

SCHEMBL17870947

SCHEMBL17870947

O=C1C[C@@H](c2ccccc2)N1CC1CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 2/20 0.43
▸ SIGMAR1 Q99720 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ GRM2 Q14416 3/20 0.41
▸ CHRM2 P08172 1/20 0.40
▸ CHRM4 P08173 1/20 0.40
▸ CHRM5 P08912 1/20 0.40
▸ CHRM1 P11229 1/20 0.40
▸ CHRM3 P20309 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ CHRNB2 P17787 1/20 0.40
▸ CHRNB4 P30926 1/20 0.40
▸ CHRNA3 P32297 1/20 0.40
▸ CHRNA7 P36544 1/20 0.40
▸ CHRNA4 P43681 1/20 0.40
▸ TP53 P04637 1/20 0.39
▸ MDM2 Q00987 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19471162 1.00 RIPK1 (0.43) RIPK1SIGMAR1ALDH1A1RAB9AKMT2A
SCHEMBL17870940 0.79 RIPK1 (0.53) RIPK1SIGMAR1ALDH1A1RAB9AKMT2A
SCHEMBL30054156 0.79 RIPK1 (0.53) RIPK1SIGMAR1ALDH1A1RAB9AKMT2A
SCHEMBL17870941 0.79 RIPK1 (0.53) RIPK1SIGMAR1ALDH1A1RAB9AKMT2A
SCHEMBL4212886 0.75 RAMP1 (0.43) ALDH1A1GRM2CHRM2CHRM4CHRM5
SCHEMBL5823194 0.75 RAMP1 (0.43) ALDH1A1GRM2CHRM2CHRM4CHRM5
SCHEMBL3245742 0.75 RAMP1 (0.43) ALDH1A1GRM2CHRM2CHRM4CHRM5
SCHEMBL19471071 0.75 CHRM2 (0.46) RIPK1SIGMAR1ALDH1A1KMT2ACHRM2
SCHEMBL17870932 0.75 CHRM2 (0.46) RIPK1SIGMAR1ALDH1A1KMT2ACHRM2
SCHEMBL28497094 0.71 RIPK1 (0.49) RIPK1SIGMAR1ALDH1A1KMT2AGRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11478438-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2022-10-25 — — US disclosed
US-11090307-B2 Treating male senescence NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-08-17 — — US disclosed
CN-107108492-B Cell necrosis inhibitor 北京生命科学研究所 2021-03-19 — — CN disclosed
US-20200182617-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-06-11 — — US disclosed
US-20200182617-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-06-11 — — US disclosed
US-20200046714-A1 Treating Male Senescence NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-02-13 — — US disclosed
US-10555920-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-02-11 — — US disclosed
US-10555920-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2020-02-11 — — US disclosed
US-20190038578-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2019-02-07 — — US disclosed
US-20190038578-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2019-02-07 — — US disclosed
US-10092529-B2 Necrosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2018-10-09 — — US disclosed
EP-3224245-B1 NECROSIS INHIBITORS NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) 2018-09-12 — — EP disclosed
US-20170304237-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2017-10-26 — — US disclosed
US-20170304237-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2017-10-26 — — US disclosed
US-20170304237-A1 Necrosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2017-10-26 — — US disclosed
EP-3224245-A1 NECROSIS INHIBITORS National Institute Of Biological Sciences, Beijing (CN) 2017-10-04 — — EP disclosed
WO-2016101887-A1 NECROSIS INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2016-06-30 — — WO disclosed
WO-2016101887-A1 NECROSIS INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2016-06-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170304237-A1 Necrosis Inhibitors RIPK3, RIPK1, RIPK4 RIPK1 2/4885SIGMAR1 1517/4885ALDH1A1 3900/4885
US-11478438-B2 Necrosis inhibitors RIPK3, RIPK1, RIPK4 RIPK1 2/4885SIGMAR1 1782/4885ALDH1A1 4104/4885
US-11090307-B2 Treating male senescence RIPK3, RIPK1, MLKL RIPK1 2/4885SIGMAR1 4777/4885ALDH1A1 2786/4885
US-20200046714-A1 Treating Male Senescence RIPK3, RIPK1, MLKL RIPK1 2/4885SIGMAR1 4777/4885ALDH1A1 2786/4885
US-20190038578-A1 Necrosis Inhibitors RIPK3, RIPK1, RIPK4 RIPK1 2/4885SIGMAR1 1782/4885ALDH1A1 4104/4885
US-10092529-B2 Necrosis inhibitors RIPK3, RIPK1, RIPK4 RIPK1 2/4885SIGMAR1 1517/4885ALDH1A1 3900/4885
US-10555920-B2 Necrosis inhibitors RIPK3, RIPK1, RIPK4 RIPK1 2/4885SIGMAR1 1782/4885ALDH1A1 4104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.