Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 15/20 | 0.83 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17873637 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1CYP2D6OPRM1CYP3A4 | |
| SCHEMBL19739295 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1CYP2D6OPRM1CYP3A4 | |
| Hydrochloric Acid SCHEMBL6479735 | 0.90 | OPRK1 (0.98) | OPRK1OPRD1CYP2D6OPRM1 | |
| Hydrochloric Acid SCHEMBL6479733 | 0.90 | OPRK1 (0.98) | OPRK1OPRD1CYP2D6OPRM1 | |
| SCHEMBL17883750 | 0.88 | OPRK1 (0.72) | OPRK1OPRD1CYP2D6OPRM1 | |
| SCHEMBL19739305 | 0.88 | OPRK1 (0.72) | OPRK1OPRD1CYP2D6OPRM1 | |
| SCHEMBL17883540 | 0.87 | OPRD1 (0.71) | OPRK1OPRD1CYP2D6OPRM1CYP3A4 | |
| SCHEMBL19739359 | 0.87 | OPRD1 (0.71) | OPRK1OPRD1CYP2D6OPRM1CYP3A4 | |
| SCHEMBL21119545 | 0.85 | OPRK1 (0.73) | OPRK1OPRD1CYP2D6CYP3A4TSHR | |
| SCHEMBL7692832 | 0.83 | OPRK1 (0.91) | OPRK1OPRD1CYP2D6OPRM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237388-A1 | N-METHYL-N-(1-PHENYL-2-(1-PYRROLIDINYL)ETHYL)-2-AMINOPHENYLACETAMIDE DERIVATIVES AGONISTS FOR THE KAPPA OPIOID RECEPTOR | Nektar Therapeutics (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016106133-A1 | N-METHYL-N-(1-PHENYL-2-(1-PYRROLIDINYL)ETHYL)-2-AMINOPHENYLACETAMIDE DERIVATIVES AGONISTS FOR THE KAPPA OPIOID RECEPTOR | NEKTAR THERAPEUTICS (US) | 2016-06-30 | — | — | WO | disclosed |