Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 4/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | RORB | Q92753 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | POLQ | O75417 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.30 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350424 | 0.86 | CDC7 (0.38) | CDC7DBF4RORBRORCROCK2 | |
| SCHEMBL17837206 | 0.84 | MAPK3 (0.37) | AAK1BACE1BACE2POLB | |
| SCHEMBL17873705 | 0.80 | MAPK1 (0.45) | CDC7DBF4 | |
| SCHEMBL17873701 | 0.75 | ROCK2 (0.37) | CDC7DBF4AAK1RORBROCK2 | |
| SCHEMBL17873704 | 0.75 | MAPK3 (0.39) | CDC7DBF4RORBRORCROCK2 | |
| SCHEMBL17837270 | 0.74 | BUB1 (0.34) | BUB1 | |
| SCHEMBL21075868 | 0.74 | BUB1 (0.34) | BUB1 | |
| SCHEMBL17873734 | 0.73 | ROCK2 (0.38) | CDC7DBF4AAK1RORBROCK2 | |
| SCHEMBL19350375 | 0.73 | MAPK3 (0.38) | CDC7DBF4ROCK2BACE1PIP4K2A | |
| SCHEMBL19373780 | 0.73 | ROCK2 (0.38) | CDC7DBF4AAK1RORBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237420-B1 | ERK INHIBITORS | LILLY CO ELI (US) | 2018-09-26 | — | — | EP | disclosed |
| US-9879029-B2 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2018-01-30 | — | — | US | disclosed |
| US-9879029-B2 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2018-01-30 | — | — | US | disclosed |
| US-9879029-B2 | ERK inhibitors | ELI LILLY AND COMPANY (US) | 2018-01-30 | — | — | US | disclosed |
| EP-3237420-A1 | ERK INHIBITORS | Eli Lilly and Company (US) | 2017-11-01 | — | — | EP | disclosed |
| US-20170267691-A1 | ERK INHIBITORS | LILLY CO ELI (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170267691-A1 | ERK INHIBITORS | LILLY CO ELI (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170267691-A1 | ERK INHIBITORS | LILLY CO ELI (US) | 2017-09-21 | — | — | US | disclosed |
| WO-2016106009-A1 | ERK INHIBITORS | ELI LILLY AND COMPANY (US) | 2016-06-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267691-A1 | ERK INHIBITORS | MAPK4, MAPK1, MAPK3 | CDC7 266/4885DBF4 3705/4885AAK1 365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.