Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | SELL | P14151 | 1/20 | 0.39 |
| ▸ | SELP | P16109 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13734585 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2RAB9ANPC1ALDH1A1HPGD | |
| SCHEMBL17102374 | 0.81 | NPC1 (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL21165525 | 0.81 | RAB9A (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL2171105 | 0.79 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL16437413 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL4857995 | 0.73 | APP (0.50) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL16441993 | 0.71 | LTA4H (0.41) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL16437408 | 0.68 | SELL (0.39) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL12046198 | 0.67 | GAA (0.52) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL1608822 | 0.67 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | SMN1; SMN2 3271/4885RAB9A 3273/4885NPC1 4638/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | SMN1; SMN2 3271/4885RAB9A 3273/4885NPC1 4638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.