Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28036731 | 0.80 | ALDH1A1 (0.44) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL5496037 | 0.78 | ALDH1A1 (0.53) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL28265003 | 0.77 | GLO1 (0.45) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL19523321 | 0.77 | MAPT (0.41) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL28166960 | 0.77 | ALDH1A1 (0.50) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL19924986 | 0.75 | — | — | |
| SCHEMBL8944831 | 0.75 | ALDH1A1 (0.48) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL14186860 | 0.75 | ALDH1A1 (0.48) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| Acetic Acid SCHEMBL9456387 | 0.73 | ALDH1A1 (0.58) | EGLN1MAPTALDH1A1LMNAHSD17B10 | |
| SCHEMBL4305928 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2709997-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | disclosed |