Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | NAE1 | Q13564 | 3/20 | 0.48 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15079618 | 1.00 | UBA6 (0.52) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL14430997 | 0.91 | UBA6 (0.51) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL192379 | 0.83 | NAE1 (0.62) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL17875227 | 0.83 | NAE1 (0.62) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL192357 | 0.77 | PRMT5 (0.45) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL13170755 | 0.75 | ADK (0.47) | UBA6METTL3 | |
| SCHEMBL192795 | 0.74 | NAE1 (0.66) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL192779 | 0.74 | NAE1 (0.61) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL17875179 | 0.74 | NAE1 (0.61) | UBA6CA2NAE1UBA3GRK5 | |
| SCHEMBL19563037 | 0.74 | ADK (0.48) | METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | disclosed |