Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866027 | 0.83 | TP53 (0.47) | TP53LMNAPOLBGAAMAPK1 | |
| SCHEMBL17866056 | 0.76 | TP53 (0.47) | TP53LMNAPOLBGAAMAPK1 | |
| SCHEMBL192667 | 0.76 | NAE1 (0.43) | TP53LMNAPOLBGAAMAPK1 | |
| SCHEMBL17865958 | 0.73 | TP53 (0.45) | TP53LMNAPOLBGAAMAPK1 | |
| SCHEMBL17875177 | 0.72 | NAE1 (0.55) | LMNAEGFR | |
| SCHEMBL5477843 | 0.72 | PRMT5 (0.55) | TP53LMNAPOLBGAAEGFR | |
| SCHEMBL17865957 | 0.71 | NAE1 (0.46) | TP53LMNAPOLBGAAMAPK1 | |
| SCHEMBL10233932 | 0.70 | CA2 (0.46) | TP53LMNAPOLBGAAMAPK1 | |
| SCHEMBL192175 | 0.69 | NAE1 (0.62) | — | |
| SCHEMBL17866032 | 0.67 | METTL3 (0.49) | TP53PRMT5WDR77METTL3METTL14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | disclosed |