SCHEMBL17876015

SCHEMBL17876015

N#Cc1ccc2c(c1)c1ccccc1n2-c1ccc2c(c1)-c1cc(-c3cc(-c4ccncc4)cc(-c4ccncc4)c3)ccc1CS(=O)(=O)C2

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FLT3 P36888 4/20 0.38
ROCK2 O75116 1/20 0.35
ROCK1 Q13464 1/20 0.35
GPR142 Q7Z601 1/20 0.32
PTGER4 P35408 1/20 0.32
CYP19A1 P11511 1/20 0.32
CYP11B1 P15538 1/20 0.32
CYP11B2 P19099 1/20 0.32
TNKS2 Q9H2K2 1/20 0.32
TRPA1 O75762 1/20 0.31
MAPK14 Q16539 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.30
ABCG2 Q9UNQ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17877841 0.93 PTGDR2 (0.34) ROCK2PTGER4PTGDR2
SCHEMBL17877842 0.91 FLT3 (0.41) FLT3CYP19A1CYP11B1CYP11B2ABCG2
SCHEMBL17876016 0.90 MEN1 (0.34) MAPK14
SCHEMBL17877790 0.88 PTGDR2 (0.33) PTGER4PTGDR2
SCHEMBL17875918 0.88 FLT3 (0.37) FLT3ROCK2ROCK1GPR142PTGER4
SCHEMBL17877859 0.88 PTGDR2 (0.36) PTGER4PTGDR2
SCHEMBL17877799 0.88 PTGDR2 (0.36) PTGER4PTGDR2
SCHEMBL17877796 0.88 PTGDR2 (0.36) PTGER4PTGDR2
SCHEMBL17877798 0.88 PTGDR2 (0.36) PTGER4PTGDR2
SCHEMBL17875816 0.87 FLT3 (0.37) FLT3ROCK2ROCK1PTGER4CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10581000-B2 Condensed cyclic compound and organic light-emitting device including the same SAMSUNG ELECTRONICS CO., LTD. (KR) 2020-03-03 US disclosed
US-20160190482-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-06-30 US disclosed
US-20160190482-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO., LTD. (KR) 2016-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10581000-B2 Condensed cyclic compound and organic light-emitting device including the same CRY1, CRY2, CCNE2 FLT3 2778/4885ROCK2 4451/4885ROCK1 3357/4885
US-20160190482-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME CRY1, CRY2, CCNE2 FLT3 2778/4885ROCK2 4451/4885ROCK1 3357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.