Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 7/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16513029 | 0.86 | CA12 (0.49) | CA12CA1CA9BRD4CREBBP | |
| SCHEMBL15189318 | 0.79 | RORC (0.40) | RORC | |
| SCHEMBL29029431 | 0.75 | HDAC3 (0.56) | CA12CA1CA9BRD4CREBBP | |
| SCHEMBL1285721 | 0.74 | IDO1 (0.45) | CA12CA1CA9BRD4CREBBP | |
| SCHEMBL29922372 | 0.73 | CA12 (0.46) | CA12CA1CA9BRD4CREBBP | |
| SCHEMBL29465938 | 0.73 | PTPRC (0.63) | — | |
| SCHEMBL22336061 | 0.73 | PTPRC (0.63) | — | |
| SCHEMBL22007092 | 0.73 | PTPRC (0.63) | CA12CA1CA9 | |
| SCHEMBL16513028 | 0.73 | PPIA (0.56) | CA12CA1CA9RXFP1 | |
| SCHEMBL13055402 | 0.72 | CYP17A1 (0.59) | CA12CA1CA9PSMB8CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889590-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2021-01-12 | — | — | US | disclosed |
| US-10233192-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2018-03-08 | — | — | US | disclosed |
| US-9777013-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | WILLIAM MARSH RICE UNIVERSITY (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | WILLIAM MARSH RICE UNIVERSITY (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10233192-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | UNC119, UNC93B1, RIOX2 | CA12 3243/4885CA1 4575/4885CA9 4046/4885 |
| US-10889590-B2 | Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents | UNC119, UNC93B1, RIOX2 | CA12 3243/4885CA1 4575/4885CA9 4046/4885 |
| US-20160185791-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | CA12 2998/4885CA1 4455/4885CA9 3562/4885 |
| US-20180065976-A1 | DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS | UNC119, UNC93B1, RIOX2 | CA12 3243/4885CA1 4575/4885CA9 4046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.