Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.57 |
| ▸ | HTR3B | O95264 | 4/20 | 0.57 |
| ▸ | HTR3A | P46098 | 4/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 4/20 | 0.53 |
| ▸ | IDO1 | P14902 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344795 | 0.85 | RIPK1 (0.56) | RIPK1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL11833353 | 0.82 | GAA (0.57) | RIPK1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL17887985 | 0.82 | RIPK1 (0.54) | RIPK1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL9824208 | 0.81 | RIPK1 (0.64) | RIPK1AOC3GAATSHRRECQL | |
| SCHEMBL11833347 | 0.81 | RIPK1 (0.52) | RIPK1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL17887509 | 0.79 | ALDH1A1 (0.61) | AOC3IDO1PYCR1 | |
| SCHEMBL29565507 | 0.79 | RIPK1 (0.65) | RIPK1AOC3GAATSHRRECQL | |
| SCHEMBL17278345 | 0.79 | RIPK1 (0.61) | RIPK1AOC3GAATSHRRECQL | |
| SCHEMBL17887869 | 0.79 | AOC3 (0.68) | AOC3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1620582 | 0.78 | NPC1 (0.60) | RIPK1AOC3TSHRGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016105448-A1 | IMIDAZOLINE RECEPTOR TYPE 1 LIGANDS FOR USE AS THERAPEUTICS | RIDEOUT DARRYL (US) | 2016-06-30 | — | — | WO | disclosed |