Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.48 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 4/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 6/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26078346 | 0.85 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| SCHEMBL26078344 | 0.77 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| SCHEMBL2843801 | 0.73 | NISCH (0.49) | ADRA1AADRA1DADRA1BNISCHADRA2A | |
| SCHEMBL954203 | 0.70 | TAAR1 (0.54) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| SCHEMBL17887764 | 0.67 | TAAR1 (0.43) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| SCHEMBL953100 | 0.67 | TAAR1 (0.62) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| Hydrochloric Acid SCHEMBL6420206 | 0.67 | ADRA1A (0.97) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL26078343 | 0.66 | ADRA1A (0.51) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| SCHEMBL955097 | 0.65 | TAAR1 (0.64) | ADRA1AADRA1DADRA1BHTR1DNISCH | |
| SCHEMBL26078355 | 0.65 | ADRA1A (0.53) | ADRA1AADRA1DADRA1BHTR1DNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016105448-A1 | IMIDAZOLINE RECEPTOR TYPE 1 LIGANDS FOR USE AS THERAPEUTICS | RIDEOUT DARRYL (US) | 2016-06-30 | — | — | WO | disclosed |