Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.39 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.39 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.39 |
| ▸ | ATG7 | O95352 | 1/20 | 0.39 |
| ▸ | UBA7 | P41226 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799044 | 0.90 | CRHR1 (0.40) | CRHR1NAE1UBA3UBA6ATG7 | |
| SCHEMBL1798707 | 0.86 | NAE1 (0.49) | CRHR1NAE1UBA3UBA6ATG7 | |
| SCHEMBL17898105 | 0.68 | NAE1 (0.71) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL5323088 | 0.68 | UBA6 (0.57) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1798066 | 0.68 | UBA6 (0.55) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1797606 | 0.68 | UBA6 (0.57) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL17889836 | 0.68 | UBA6 (0.57) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1798071 | 0.68 | UBA6 (0.55) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1797603 | 0.68 | UBA6 (0.57) | NAE1UBA3UBA6ATG7UBA7 | |
| SCHEMBL1798070 | 0.68 | UBA6 (0.55) | NAE1UBA3UBA6ATG7UBA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170073367-A9 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENIUM PHARMACEUTICALS, INC. | 2017-03-16 | — | — | US | disclosed |
| US-20160194348-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARM INC (US) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073367-A9 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | CRHR1 3000/4885NAE1 257/4885UBA3 235/4885 |
| US-20160194348-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | CRHR1 3000/4885NAE1 257/4885UBA3 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.