Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 10/20 | 0.38 |
| ▸ | MAOB | P27338 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371169 | 0.96 | GRIA4 (0.44) | GRIA4KDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL4606634 | 0.96 | GRIA4 (0.44) | GRIA4KDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL4258361 | 0.79 | HTR3A (0.46) | GRIA4KDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL1646753 | 0.79 | HTR2A (0.44) | GRIA4KDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL4258364 | 0.79 | HTR3A (0.46) | GRIA4KDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL13598557 | 0.79 | KDM1A (0.63) | KDM1AMAOBKCNH2RCOR1KDM1B | |
| SCHEMBL1644778 | 0.79 | HTR3A (0.46) | GRIA4KDM1AMAOBKCNH2RCOR1 | |
| SCHEMBL12261925 | 0.78 | MAOB (0.60) | KDM1AMAOBKCNH2RCOR1KDM1B | |
| SCHEMBL10494836 | 0.78 | MAOB (0.60) | KDM1AMAOBKCNH2RCOR1KDM1B | |
| SCHEMBL445956 | 0.78 | MAOB (0.60) | KDM1AMAOBKCNH2RCOR1KDM1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |