Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30732493 | 0.76 | KDM4E (0.32) | KMT2A | |
| Trifluoroacetic Acid SCHEMBL16342428 | 0.74 | HCAR2 (0.38) | KMT2ACES1L3MBTL1HCAR2 | |
| Trifluoroacetic Acid SCHEMBL4627267 | 0.70 | HRH4 (0.43) | CES1L3MBTL1KDM1AHRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL30967251 | 0.70 | HRH4 (0.43) | CES1L3MBTL1KDM1AHRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL30870503 | 0.69 | L3MBTL1 (0.31) | L3MBTL1HCAR2 | |
| Trifluoroacetic Acid SCHEMBL27518491 | 0.68 | HRH4 (0.30) | HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL23457501 | 0.68 | HCAR2 (0.35) | HCAR2HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL6273635 | 0.65 | CES1 (0.33) | CES1 | |
| Trifluoroacetic Acid SCHEMBL27773891 | 0.64 | CES1 (0.37) | CES1L3MBTL1HCAR2HRH4HRH3 | |
| Trifluoroacetic Acid SCHEMBL29009901 | 0.62 | CYP2C9 (0.46) | CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3240790-A1 | PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS FOR THE TREATMENT OF CANCER | Forma Therapeutics, Inc. (US) | 2017-11-08 | — | — | EP | disclosed |
| WO-2016109480-A1 | PYRROLOTRIAZINONE AND IMIDAZOTRIAZINONE DERIVATIVES AS UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |