Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.60 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.54 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1968503 | 0.84 | ALOX15 (0.60) | RIOK2SORT1ALOX15TSHRCASP1 | |
| SCHEMBL30643207 | 0.82 | EPAS1 (0.59) | RIOK2EPAS1GRM4MEN1ALDH1A1 | |
| SCHEMBL16762179 | 0.81 | EPAS1 (0.55) | TLR7RIOK2EPAS1BRAFALDH1A1 | |
| SCHEMBL30362400 | 0.81 | TRPV1 (0.57) | RIOK2EPAS1MEN1ALDH1A1KMT2A | |
| SCHEMBL28290705 | 0.80 | KMT2A (0.71) | TLR7GRM4BRAFCES1MEN1 | |
| SCHEMBL30360592 | 0.80 | KMT2A (0.71) | TLR7GRM4BRAFCES1MEN1 | |
| Formic Acid SCHEMBL30595912 | 0.80 | ALOX15 (0.55) | RIOK2EPAS1SORT1ALOX15TSHR | |
| SCHEMBL15877592 | 0.80 | GRM5 (0.48) | RIOK2EPAS1MEN1ALDH1A1KMT2A | |
| SCHEMBL13173412 | 0.79 | TLR7 (0.54) | TLR7GRM4BRAFCES1 | |
| SCHEMBL11483728 | 0.79 | GRM4 (0.63) | TLR7RIOK2GRM4TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016106625-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-07-07 | — | — | WO | disclosed |