Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 15/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22099692 | 0.85 | BRD4 (0.69) | BRD4 | |
| SCHEMBL22099672 | 0.83 | ALDH1A1 (0.47) | ALDH1A1BRD4IKBKBLCK | |
| SCHEMBL28455718 | 0.83 | BRD4 (0.70) | BRD4 | |
| SCHEMBL22099674 | 0.82 | BRD4 (0.71) | BRD4 | |
| SCHEMBL17895236 | 0.80 | ALDH1A1 (0.44) | ALDH1A1BRD4KDM4E | |
| SCHEMBL17895294 | 0.79 | MAPK8 (0.57) | ALDH1A1BRD4KDM4EIKBKB | |
| SCHEMBL17895172 | 0.77 | ALDH1A1 (0.43) | ALDH1A1BRD4IKBKBLCK | |
| SCHEMBL22099691 | 0.77 | BRD4 (0.43) | BRD4IKBKB | |
| SCHEMBL17895254 | 0.76 | BRD4 (0.50) | BRD4IKBKB | |
| SCHEMBL121917 | 0.75 | KMT2A (0.49) | BRD4IKBKBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107454900-B | Novel imidazo [1,2-A ] quinoxalines and derivatives thereof for the treatment of cancer | 蒙彼利埃大学 | 2020-08-07 | — | — | CN | disclosed |
| EP-3240789-B1 | NEW IMIDAZO[1,2-A]QUINOXALINES AND DERIVATES THEREOF FOR THE TREATMENT OF CANCER | UNIV MONTPELLIER (FR) | 2020-07-29 | — | — | EP | disclosed |
| EP-3240789-A1 | NEW IMIDAZO[1,2-A]QUINOXALINES AND DERIVATES THEREOF FOR THE TREATMENT OF CANCER | Université de Montpellier (FR) | 2017-11-08 | — | — | EP | disclosed |
| WO-2016107895-A1 | NEW IMIDAZO[1,2-A]QUINOXALINES AND DERIVATES THEREOF FOR THE TREATMENT OF CANCER | UNIVERSITE DE MONTPELLIER (FR) | 2016-07-07 | — | — | WO | disclosed |