Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 7/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28466382 | 0.84 | BRD4 (0.66) | MAPK8BRD4 | |
| SCHEMBL22099666 | 0.83 | MAPK8 (0.69) | MAPK8ALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL28463722 | 0.83 | BRD4 (0.67) | MAPK8BRD4 | |
| SCHEMBL28459026 | 0.82 | BRD4 (0.68) | MAPK8BRD4 | |
| SCHEMBL17895249 | 0.79 | ALDH1A1 (0.51) | ALDH1A1BRD4KDM4EIKBKB | |
| SCHEMBL30473266 | 0.76 | BRD4 (0.48) | MAPK8BRD4HTR3EHTR3BHTR3A | |
| SCHEMBL17894988 | 0.76 | MAPK8 (0.49) | MAPK8ALDH1A1BRD4HTR3EHTR3B | |
| SCHEMBL8103067 | 0.75 | MAPK8 (0.73) | MAPK8ALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL8118265 | 0.75 | MAPK8 (0.73) | MAPK8ALDH1A1HTR3EHTR3BHTR3A | |
| SCHEMBL17895299 | 0.75 | MAPK8 (0.69) | MAPK8BRD4HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107454900-B | Novel imidazo [1,2-A ] quinoxalines and derivatives thereof for the treatment of cancer | 蒙彼利埃大学 | 2020-08-07 | — | — | CN | disclosed |
| EP-3240789-B1 | NEW IMIDAZO[1,2-A]QUINOXALINES AND DERIVATES THEREOF FOR THE TREATMENT OF CANCER | UNIV MONTPELLIER (FR) | 2020-07-29 | — | — | EP | disclosed |
| EP-3240789-A1 | NEW IMIDAZO[1,2-A]QUINOXALINES AND DERIVATES THEREOF FOR THE TREATMENT OF CANCER | Université de Montpellier (FR) | 2017-11-08 | — | — | EP | disclosed |
| WO-2016107895-A1 | NEW IMIDAZO[1,2-A]QUINOXALINES AND DERIVATES THEREOF FOR THE TREATMENT OF CANCER | UNIVERSITE DE MONTPELLIER (FR) | 2016-07-07 | — | — | WO | disclosed |