Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957634 | 0.82 | — | — | |
| SCHEMBL5368005 | 0.79 | ADORA2A (0.50) | NPSR1MAPTADORA2AADORA1LMNA | |
| SCHEMBL5368001 | 0.79 | ADORA2A (0.46) | NPSR1MAPTPOLBADORA2AADORA1 | |
| SCHEMBL15722722 | 0.78 | MAPT (0.53) | NPSR1MAPTPOLBADORA2AADORA1 | |
| Bromide SCHEMBL6183691 | 0.77 | NPSR1 (0.50) | NPSR1MAPTPOLBPKMADORA2B | |
| SCHEMBL4216446 | 0.75 | NPSR1 (0.49) | NPSR1MAPTPOLBADORA2APKM | |
| SCHEMBL5378181 | 0.75 | YTHDC1 (0.40) | MAPTADORA2AADORA1LMNAADORA2B | |
| SCHEMBL5378096 | 0.75 | CYP1A2 (0.40) | NPSR1MAPTADORA2AADORA1LMNA | |
| SCHEMBL5378177 | 0.75 | LMNA (0.37) | NPSR1MAPTPOLBADORA2AADORA1 | |
| SCHEMBL5378094 | 0.75 | LMNA (0.37) | NPSR1MAPTPOLBADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |