Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DUT | P33316 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA4 | P22748 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3536391 | 0.97 | PLK1 (0.50) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL17895883 | 0.93 | PLK1 (0.45) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL20557386 | 0.75 | ELANE (0.35) | ELANEDUTBUB1 | |
| SCHEMBL9149384 | 0.74 | PLK1 (0.63) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL17895891 | 0.73 | PLK1 (0.57) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL3533622 | 0.73 | DUT (0.30) | DUT | |
| SCHEMBL3537808 | 0.73 | NPC1 (0.30) | DUT | |
| SCHEMBL3531363 | 0.71 | PLK1 (0.58) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL9142953 | 0.70 | PLK1 (0.62) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL21003834 | 0.69 | PLK1 (0.49) | PLK1CSNK2A1PLK3ELANEHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109706-A1 | FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |