Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.63 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | CA4 | P22748 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 4/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9142953 | 0.87 | PLK1 (0.62) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL3531363 | 0.84 | PLK1 (0.58) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL17895891 | 0.83 | PLK1 (0.57) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL27832842 | 0.79 | PLK1 (0.52) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL1986758 | 0.78 | PLK1 (1.00) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL3536391 | 0.77 | PLK1 (0.50) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL7489227 | 0.76 | PLK1 (0.53) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL700290 | 0.76 | ELANE (0.51) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL9149060 | 0.74 | DRD4 (0.57) | PLK1CSNK2A1PLK3DRD4DRD2 | |
| SCHEMBL3142557 | 0.74 | PLK1 (0.93) | PLK1CSNK2A1PLK3HTTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0590558-B1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | THOMAE GMBH DR K (DE) | 1995-12-06 | — | — | EP | disclosed |
| US-5468766-A | Analgesics, antipyretics, antiphlogistics | DR. KARL THOMAE GMBH (DE) | 1995-11-21 | — | — | US | disclosed |
| EP-0590558-A1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | Dr. Karl Thomae GmbH (DE) | 1994-04-06 | — | — | EP | disclosed |