Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 12/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10175581 | 0.88 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP19A1ADRA2BADRB1 | |
| SCHEMBL17896619 | 0.87 | NPC1 (0.51) | CYP11B2CYP11B1CYP19A1ADRA2BATM | |
| SCHEMBL17896665 | 0.87 | KDM4E (0.52) | CYP11B2CYP11B1CYP19A1ADRA2BATM | |
| SCHEMBL17896628 | 0.85 | HTR2B (0.46) | CYP11B2CYP11B1CYP19A1ADRA2BATM | |
| SCHEMBL10175433 | 0.85 | CYP11B1 (0.53) | CYP11B2CYP11B1CA12CA1CA2 | |
| SCHEMBL10175815 | 0.85 | CYP11B1 (0.48) | CYP11B2CYP11B1CYP19A1ADRA2BMAPT | |
| SCHEMBL17896641 | 0.84 | CYP11B2 (0.47) | CYP11B2CYP11B1CYP19A1ADRA2BATM | |
| SCHEMBL17896599 | 0.84 | CYP11B2 (0.63) | CYP11B2CYP11B1CYP19A1ADRA2BHTR2B | |
| SCHEMBL17896730 | 0.83 | PTGER4 (0.52) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL10175126 | 0.83 | CA12 (0.53) | CYP11B2CYP11B1CYP19A1ADRA2BCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |