Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 13/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17896612 | 0.90 | CYP11B2 (0.52) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL10175348 | 0.87 | CYP11B2 (0.48) | CYP11B2CYP11B1KDM4EALDH1A1GLA | |
| SCHEMBL10175342 | 0.85 | CYP11B2 (0.46) | CYP11B2CYP11B1KDM4EALDH1A1GLA | |
| SCHEMBL17883795 | 0.84 | CYP11B2 (0.47) | CYP11B2CYP11B1 | |
| SCHEMBL17896718 | 0.84 | CYP11B2 (0.56) | CYP11B2CYP11B1CYP19A1ADRA2BATM | |
| SCHEMBL17896642 | 0.83 | ALOX5AP (0.46) | CYP11B2CYP11B1PTGER4 | |
| SCHEMBL17896644 | 0.82 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP19A1ADRA2B | |
| SCHEMBL10175439 | 0.81 | CYP11B2 (0.46) | CYP11B2CYP11B1ATM | |
| SCHEMBL4243953 | 0.81 | CYP11B2 (0.69) | CYP11B2CYP11B1CYP19A1ATM | |
| SCHEMBL17896665 | 0.81 | KDM4E (0.52) | CYP11B2CYP11B1CYP19A1ADRA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |
| US-9382226-B2 | Aldosterone synthase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-07-05 | — | — | US | disclosed |