Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TLR2 | O60603 | 1/20 | 0.34 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.34 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705407 | 0.86 | TDP1 (0.50) | TDP1LMNAKMT2AMEN1THRB | |
| SCHEMBL17898004 | 0.84 | CYP2C9 (0.40) | TDP1LMNAKMT2AMEN1THRB | |
| SCHEMBL28352956 | 0.82 | TDP1 (0.50) | TDP1LMNAKMT2AMEN1THRB | |
| SCHEMBL12446803 | 0.79 | TDP1 (0.43) | TDP1LMNAKMT2AMEN1THRB | |
| SCHEMBL29593649 | 0.79 | CYP3A4 (0.58) | TDP1CYP3A4DRD1GAAESR1 | |
| Ethylenediamine SCHEMBL29033280 | 0.78 | TDP1 (0.41) | TDP1LMNAKMT2AMEN1THRB | |
| Aniline SCHEMBL28503683 | 0.78 | TDP1 (0.41) | TDP1LMNAKMT2AMEN1THRB | |
| SCHEMBL31003883 | 0.78 | LMNA (0.41) | TDP1LMNAKMT2AMEN1THRB | |
| SCHEMBL10700827 | 0.73 | CYP3A4 (0.50) | TDP1LMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL21734336 | 0.72 | LMNA (0.60) | TDP1LMNAKMT2AMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170158703-A9 | METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-06-08 | — | — | US | disclosed |
| US-20160194331-A1 | METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2016-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194331-A1 | METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE | MDM2, TP53, RB1 | TDP1 2527/4885LMNA 2666/4885KMT2A 3528/4885 |
| US-20170158703-A9 | METHOD FOR PRODUCING SPIROOXINDOLE DERIVATIVE | MDM2, TP53, RB1 | TDP1 2527/4885LMNA 2666/4885KMT2A 3528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.