Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705407 | 0.91 | TDP1 (0.50) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL28352956 | 0.87 | TDP1 (0.50) | TDP1KMT2ALMNAMEN1THRB | |
| Aniline SCHEMBL28503683 | 0.86 | TDP1 (0.41) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL31003883 | 0.82 | LMNA (0.41) | TDP1KMT2ALMNAMEN1THRB | |
| Aniline SCHEMBL28514619 | 0.79 | MEN1 (0.32) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL21734336 | 0.78 | LMNA (0.60) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL31218232 | 0.78 | LMNA (0.60) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL17898003 | 0.78 | TDP1 (0.44) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL29033277 | 0.78 | TDP1 (0.34) | TDP1KMT2ALMNAMEN1THRB | |
| SCHEMBL13272710 | 0.77 | LOXL2 (0.35) | TDP1KMT2ALMNAMEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114289073-B | Method for producing hydrogen by reforming methanol and water by using Schiff base metal complex in homogeneous phase catalysis | 长春工业大学 | 2023-07-18 | — | — | CN | disclosed |