Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19091129 | 0.95 | MERTK (0.35) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL15373805 | 0.93 | MERTK (0.38) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL15373755 | 0.93 | MERTK (0.38) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL15366475 | 0.93 | MERTK (0.38) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL15366755 | 0.93 | MERTK (0.38) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL15373806 | 0.93 | MERTK (0.38) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL19628447 | 0.90 | MERTK (0.36) | LRRK2MERTKAXLNAAAPSEN1 | |
| SCHEMBL17899020 | 0.90 | TAS1R3 (0.37) | MERTKAXLNAAATAS1R3TAS1R1 | |
| SCHEMBL15844257 | 0.90 | TAS1R3 (0.37) | MERTKAXLNAAATAS1R3TAS1R1 | |
| SCHEMBL17899006 | 0.88 | LRRK2 (0.32) | LRRK2MERTKAXLNAAACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109291-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016109290-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2016-07-07 | — | — | WO | disclosed |