Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.31 |
| ▸ | MMP8 | P22894 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17892926 | 0.84 | RCE1 (0.39) | RCE1HTTMAPT | |
| SCHEMBL17898732 | 0.80 | RCE1 (0.39) | RCE1HTTMAPTMMP9MMP8 | |
| SCHEMBL17898990 | 0.79 | RCE1 (0.44) | RCE1HTTMAPTMMP9MMP8 | |
| SCHEMBL17898737 | 0.79 | RCE1 (0.38) | RCE1HTTMAPTMMP9MMP8 | |
| SCHEMBL16594271 | 0.77 | ALDH1A1 (0.35) | HTTMAPT | |
| SCHEMBL16594269 | 0.77 | ALDH1A1 (0.35) | HTTMAPT | |
| SCHEMBL13207896 | 0.74 | MAPT (0.36) | RCE1HTTMAPT | |
| SCHEMBL21440871 | 0.71 | RCE1 (0.48) | RCE1HTTMAPTMMP9MMP8 | |
| SCHEMBL24241193 | 0.71 | RCE1 (0.39) | RCE1HTTMAPTMMP9MMP8 | |
| SCHEMBL17896260 | 0.71 | RCE1 (0.39) | RCE1HTTMAPTMMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2018-01-04 | — | — | US | disclosed |
| WO-2016109290-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | DOW AGROSCIENCES LLC (US) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016109291-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180002320-A1 | USE OF MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | CYP4F12, CYP1A2, CYP4F2 | RCE1 553/4885HTT 3680/4885MAPT 2077/4885 |
| US-20180002319-A1 | MACROCYCLIC PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY | AADAC, CYP51A1, PFAS | RCE1 372/4885HTT 3467/4885MAPT 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.