Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.71 |
| ▸ | IKBKB | O14920 | 5/20 | 0.71 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.71 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.71 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.71 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.71 |
| ▸ | RAF1 | P04049 | 3/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.71 |
| ▸ | AKT1 | P31749 | 3/20 | 0.71 |
| ▸ | AKT2 | P31751 | 3/20 | 0.71 |
| ▸ | KDR | P35968 | 3/20 | 0.71 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.71 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.71 |
| ▸ | PRDX1 | Q06830 | 1/20 | 0.59 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17899480 | 0.88 | SMN1; SMN2 (0.80) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL27218175 | 0.83 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL29437157 | 0.83 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL8120726 | 0.83 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL17899578 | 0.79 | MAPK1 (0.71) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL17899568 | 0.77 | NPC1 (0.71) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL17899506 | 0.76 | ALDH1A1 (0.68) | MAPK1SMN1; SMN2RAB9AMAPTALDH1A1 | |
| SCHEMBL17899571 | 0.76 | SMN1; SMN2 (0.56) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL31518771 | 0.76 | ACHE (0.58) | MAPK1IKBKBPRKAG1PRKAA1NEK1 | |
| SCHEMBL8106620 | 0.74 | IKBKB (1.00) | MAPK1IKBKBPRKAG1PRKAA1NEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-09 | — | — | US | disclosed |
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-09 | — | — | US | disclosed |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2023-07-25 | — | — | US | disclosed |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2023-07-25 | — | — | US | disclosed |
| US-11312676-B2 | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer | BAYLOR COLLEGE OF MEDICINE (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210115017-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2021-04-22 | — | — | US | disclosed |
| US-10875841-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200071300-A1 | Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents | BAYLOR COLLEGE OF MEDICINE (US) | 2020-03-05 | — | — | US | disclosed |
| WO-2016109470-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER | BAYLOR COLLEGE OF MEDICINE (US) | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071300-A1 | Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents | NCOA3, FABP3, NCOA1 | MAPK1 1806/4885IKBKB 533/4885PRKAG1 346/4885 |
| US-11312676-B2 | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer | NCOA2, NCOA1, NCOA3 | MAPK1 2693/4885IKBKB 509/4885PRKAG1 175/4885 |
| US-20210115017-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | MAPK1 1806/4885IKBKB 533/4885PRKAG1 346/4885 |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | MAPK1 1806/4885IKBKB 533/4885PRKAG1 346/4885 |
| US-10875841-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | MAPK1 1806/4885IKBKB 533/4885PRKAG1 346/4885 |
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | MAPK1 1806/4885IKBKB 533/4885PRKAG1 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.