Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ATM | Q13315 | 2/20 | 0.59 |
| ▸ | MDM4 | O15151 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.59 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25842387 | 0.93 | MAPT (0.53) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17899497 | 0.84 | ACHE (0.61) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17899554 | 0.83 | MAOB (0.57) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17899518 | 0.83 | NFE2L2 (0.58) | MAPTSMN1; SMN2RAB9ALMNAHTT | |
| SCHEMBL21792987 | 0.79 | MEN1 (0.62) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17899533 | 0.79 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2RAB9ALMNAHTT | |
| SCHEMBL25842383 | 0.79 | MAOB (0.55) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL25842373 | 0.77 | NFE2L2 (0.52) | MAPTSMN1; SMN2RAB9ALMNAHTT | |
| SCHEMBL17899529 | 0.77 | MEN1 (0.59) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL17899574 | 0.76 | MEN1 (0.57) | MAPTSMN1; SMN2LMNAHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2023-11-09 | — | — | US | disclosed |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2023-07-25 | — | — | US | disclosed |
| US-11312676-B2 | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer | BAYLOR COLLEGE OF MEDICINE (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210115017-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | BAYLOR COLLEGE OF MEDICINE (US) | 2021-04-22 | — | — | US | disclosed |
| US-10875841-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | BAYLOR COLLEGE OF MEDICINE (US) | 2020-12-29 | — | — | US | disclosed |
| US-20200071300-A1 | Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents | BAYLOR COLLEGE OF MEDICINE (US) | 2020-03-05 | — | — | US | disclosed |
| WO-2016109470-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER | BAYLOR COLLEGE OF MEDICINE (US) | 2016-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071300-A1 | Small Molecule Stimulators of Steroid Receptor Coactivator-3 and Methods of Their Use as Cardioprotective and/or Vascular Regenerative Agents | NCOA3, FABP3, NCOA1 | MAPT 4809/4885SMN1; SMN2 3684/4885NPC1 4666/4885 |
| US-11312676-B2 | Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer | NCOA2, NCOA1, NCOA3 | MAPT 4834/4885SMN1; SMN2 4722/4885NPC1 3993/4885 |
| US-20210115017-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | MAPT 4809/4885SMN1; SMN2 3684/4885NPC1 4666/4885 |
| US-11708350-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | MAPT 4809/4885SMN1; SMN2 3684/4885NPC1 4666/4885 |
| US-10875841-B2 | Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents | NCOA3, FABP3, NCOA1 | MAPT 4809/4885SMN1; SMN2 3684/4885NPC1 4666/4885 |
| US-20230357200-A1 | SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR-3 AND METHODS OF THEIR USE AS CARDIOPROTECTIVE AND/OR VASCULAR REGENERATIVE AGENTS | NCOA3, FABP3, NCOA1 | MAPT 4809/4885SMN1; SMN2 3684/4885NPC1 4666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.