Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16531967 | 0.91 | DGAT1 (0.51) | DGAT1TP53 | |
| SCHEMBL16532105 | 0.90 | DGAT1 (0.51) | DGAT1TP53 | |
| SCHEMBL16531982 | 0.87 | DGAT1 (0.49) | DGAT1TP53ALDH1A1 | |
| SCHEMBL17907301 | 0.86 | DGAT1 (0.49) | DGAT1TP53 | |
| SCHEMBL16532112 | 0.85 | DGAT1 (0.51) | DGAT1TP53 | |
| SCHEMBL17907290 | 0.84 | DGAT1 (0.50) | DGAT1TP53 | |
| SCHEMBL16532013 | 0.84 | DGAT1 (0.49) | DGAT1TP53 | |
| SCHEMBL17907288 | 0.82 | DGAT1 (0.47) | DGAT1TP53 | |
| SCHEMBL16532008 | 0.79 | DGAT1 (0.62) | DGAT1TP53 | |
| SCHEMBL17907383 | 0.79 | DGAT1 (0.48) | DGAT1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3042907-A1 | DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF | Medshine Discovery Inc. (CN) | 2016-07-13 | — | — | EP | disclosed |