SCHEMBL17907383

SCHEMBL17907383

CCC(C(=O)O)N1CCN(c2ccc(N(CCO[Si](C)(C)C(C)(C)C)C(=O)c3c(Cl)ncnc3Cl)cc2F)C1=O

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 4/20 0.48
TP53 P04637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17907301 0.93 DGAT1 (0.49) DGAT1TP53
SCHEMBL16532013 0.84 DGAT1 (0.49) DGAT1TP53
SCHEMBL17907389 0.81 TP53 (0.37) DGAT1TP53
SCHEMBL17907369 0.79 DGAT1 (0.51) DGAT1TP53
SCHEMBL16532105 0.78 DGAT1 (0.51) DGAT1TP53
SCHEMBL16532112 0.76 DGAT1 (0.51) DGAT1TP53
SCHEMBL16531967 0.76 DGAT1 (0.51) DGAT1TP53
SCHEMBL16532036 0.76 DGAT1 (0.58) DGAT1TP53
SCHEMBL17907290 0.76 DGAT1 (0.50) DGAT1TP53
SCHEMBL16531982 0.75 DGAT1 (0.49) DGAT1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3042907-A1 DGAT1 INHIBITOR AND PREPARATION METHOD AND USE THEREOF Medshine Discovery Inc. (CN) 2016-07-13 EP disclosed