Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 2/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907944 | 1.00 | ALDH1A1 (0.37) | ALDH1A1KDM4EPLA2G7CCR2NTRK1 | |
| SCHEMBL17907997 | 0.91 | CACNA1B (0.40) | ALDH1A1KDM4EPLA2G7CCR2NTRK1 | |
| SCHEMBL17907996 | 0.91 | CACNA1B (0.40) | ALDH1A1KDM4EPLA2G7CCR2NTRK1 | |
| SCHEMBL17907939 | 0.88 | CCR9 (0.42) | ALDH1A1KDM4ECCR2CACNA1BSMN1; SMN2 | |
| SCHEMBL17907937 | 0.88 | CCR9 (0.42) | ALDH1A1KDM4ECCR2CACNA1BSMN1; SMN2 | |
| SCHEMBL17907946 | 0.87 | PDE5A (0.40) | ALDH1A1KDM4ECCR2CACNA1BLMNA | |
| SCHEMBL17907948 | 0.87 | PDE5A (0.40) | ALDH1A1KDM4ECCR2CACNA1BLMNA | |
| SCHEMBL3553079 | 0.86 | KDM4E (0.46) | ALDH1A1KDM4ECCR2CACNA1BKMT2A | |
| SCHEMBL3553083 | 0.86 | KDM4E (0.46) | ALDH1A1KDM4ECCR2CACNA1BKMT2A | |
| SCHEMBL17907927 | 0.82 | CACNA1B (0.44) | ALDH1A1KDM4ECACNA1BMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |