Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 9/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907953 | 1.00 | TDP1 (0.41) | TDP1CCR2CACNA1BKDM4EALDH1A1 | |
| SCHEMBL17907939 | 0.91 | CCR9 (0.42) | CCR2CACNA1BKDM4EALDH1A1HPGD | |
| SCHEMBL17907937 | 0.91 | CCR9 (0.42) | CCR2CACNA1BKDM4EALDH1A1HPGD | |
| SCHEMBL17907996 | 0.88 | CACNA1B (0.40) | CCR2CACNA1BKDM4EALDH1A1LMNA | |
| SCHEMBL17907997 | 0.88 | CACNA1B (0.40) | CCR2CACNA1BKDM4EALDH1A1LMNA | |
| SCHEMBL17907928 | 0.88 | CACNA1B (0.44) | TDP1CACNA1BKDM4EALDH1A1 | |
| SCHEMBL17907927 | 0.88 | CACNA1B (0.44) | TDP1CACNA1BKDM4EALDH1A1 | |
| SCHEMBL17907985 | 0.87 | KDM4E (0.41) | CCR2CACNA1BKDM4EALDH1A1THRB | |
| SCHEMBL17907984 | 0.87 | KDM4E (0.41) | CCR2CACNA1BKDM4EALDH1A1THRB | |
| SCHEMBL3553079 | 0.85 | KDM4E (0.46) | CCR2CACNA1BKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |