Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907927 | 1.00 | CACNA1B (0.44) | CACNA1BALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL17907997 | 0.89 | CACNA1B (0.40) | CACNA1BALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL17907996 | 0.89 | CACNA1B (0.40) | CACNA1BALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL17907985 | 0.88 | KDM4E (0.41) | CACNA1BALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL17907984 | 0.88 | KDM4E (0.41) | CACNA1BALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL17907951 | 0.88 | TDP1 (0.41) | CACNA1BALDH1A1KDM4ETDP1 | |
| SCHEMBL17907953 | 0.88 | TDP1 (0.41) | CACNA1BALDH1A1KDM4ETDP1 | |
| SCHEMBL3553079 | 0.86 | KDM4E (0.46) | CACNA1BALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL3553083 | 0.86 | KDM4E (0.46) | CACNA1BALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL17907933 | 0.86 | KCNQ3 (0.38) | CACNA1BALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |