Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 5/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907976 | 0.85 | PTGDR2 (0.39) | PTGDR2CHRNA7 | |
| SCHEMBL13279281 | 0.83 | HTR2A (0.40) | HTR2AHTR2CNOTUMCNR1CNR2 | |
| SCHEMBL14745400 | 0.72 | USP30 (0.39) | USP30KRASKMOKMT2A | |
| SCHEMBL26912344 | 0.71 | PTGDR2 (0.31) | PTGDR2 | |
| SCHEMBL21028086 | 0.69 | SMN1; SMN2 (0.39) | HTR2AHTR2CKMT2A | |
| SCHEMBL26913213 | 0.68 | HTT (0.31) | KRAS | |
| SCHEMBL1534166 | 0.66 | NOTUM (0.61) | NOTUMCNR1USP30KMT2A | |
| SCHEMBL17907974 | 0.66 | NOS3 (0.41) | PTGDR2HTR2AHTR2CCNR1CNR2 | |
| SCHEMBL17784836 | 0.66 | NOTUM (0.64) | PTGDR2HTR2ANOTUMCNR1KMT2A | |
| SCHEMBL1800356 | 0.66 | NOTUM (0.64) | PTGDR2HTR2ANOTUMCNR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |