Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.39 |
| ▸ | CCR3 | P51677 | 14/20 | 0.38 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907979 | 0.85 | PTGDR2 (0.39) | PTGDR2CHRNA7 | |
| SCHEMBL13279281 | 0.83 | HTR2A (0.40) | — | |
| SCHEMBL14745400 | 0.72 | USP30 (0.39) | — | |
| SCHEMBL21028295 | 0.69 | SIGMAR1 (0.38) | HPGD | |
| SCHEMBL17907975 | 0.68 | CCR3 (0.50) | CCR3 | |
| SCHEMBL233004 | 0.67 | TBXA2R (0.55) | PTGDR2CCR3 | |
| SCHEMBL16422984 | 0.66 | NOTUM (0.61) | — | |
| SCHEMBL16422687 | 0.66 | NOTUM (0.61) | — | |
| SCHEMBL16422685 | 0.66 | NOTUM (0.61) | — | |
| SCHEMBL17907929 | 0.66 | CYP2D6 (0.42) | PTGDR2CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |