Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 2/20 | 0.74 |
| ▸ | MMP2 | P08253 | 4/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP8 | P22894 | 4/20 | 0.48 |
| ▸ | MMP13 | P45452 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022264 | 0.95 | TOP2A (0.65) | TOP2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL8666363 | 0.92 | TOP2A (0.64) | TOP2AMMP2MMP9MMP8MMP13 | |
| SCHEMBL17929365 | 0.90 | TOP2A (0.72) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17929350 | 0.86 | TOP2A (0.83) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17929361 | 0.86 | TOP2A (0.83) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17929348 | 0.86 | TOP2A (1.00) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17929364 | 0.85 | TOP2A (0.71) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17929353 | 0.85 | TOP2A (0.81) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17931471 | 0.85 | TOP2A (0.81) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17929354 | 0.85 | TOP2A (0.81) | TOP2ANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160207909-A1 | Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof | HUANG YUNG-TZUNG (TW) | 2016-07-21 | — | — | US | disclosed |
| US-20160207909-A1 | Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof | HUANG YUNG-TZUNG (TW) | 2016-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207909-A1 | Synthesis Method of Anti-Cancer Drug UK-1 and Derivatives Thereof | ALDH7A1, ADH1A, ALDH1A1 | TOP2A 300/4885MMP2 429/4885MMP9 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.