Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 5/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.41 |
| ▸ | CSK | P41240 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | LTK | P29376 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17935694 | 0.89 | ADORA3 (0.54) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL17935695 | 0.87 | ADORA3 (0.52) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL23620924 | 0.83 | TLR7 (0.44) | ADORA3ADORA2AADORA2BADORA1TLR7 | |
| SCHEMBL17935591 | 0.75 | ADORA2A (0.55) | ADORA3ADORA2AADORA2BADORA1PIK3CD | |
| SCHEMBL23621142 | 0.70 | ADORA2A (0.49) | ADORA3ADORA2AADORA2BADORA1LCK | |
| SCHEMBL23621027 | 0.68 | ADORA2A (0.47) | ADORA3ADORA2AADORA2BADORA1LCK | |
| SCHEMBL12940530 | 0.66 | NSD3 (0.58) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL4055632 | 0.66 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1FBP1 | |
| SCHEMBL2195761 | 0.64 | TLR7 (0.55) | TLR7 | |
| SCHEMBL4054762 | 0.64 | ADORA2A (1.00) | ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210361660-A1 | SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISORDERS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2021-11-25 | — | — | US | disclosed |
| US-20190169190-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-06-06 | — | — | US | disclosed |
| US-20180009809-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-01-11 | — | — | US | disclosed |
| WO-2016115487-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | JIANG JEAN X (US) | 2016-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210361660-A1 | SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISORDERS | P2RY2, P2RY1, P2RX2 | ADORA3 16/4885ADORA2A 4/4885ADORA2B 17/4885 |
| US-20190169190-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | ADORA2A, ADORA1, ADORA3 | ADORA3 3/4885ADORA2A 1/4885ADORA2B 4/4885 |
| US-20180009809-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | ADORA2A, ADORA1, ADORA3 | ADORA3 3/4885ADORA2A 1/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.