Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23621142 | 0.87 | ADORA2A (0.49) | ADORA2AADORA2BADORA1ADORA3FBP1 | |
| SCHEMBL23621027 | 0.85 | ADORA2A (0.47) | ADORA2AADORA2BADORA1ADORA3FBP1 | |
| SCHEMBL17935693 | 0.83 | ADORA3 (0.47) | TLR7ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL29394367 | 0.76 | ADORA2A (0.65) | ADORA2AADORA2BADORA1ADORA3FBP1 | |
| SCHEMBL15689328 | 0.76 | ADORA2A (0.65) | ADORA2AADORA2BADORA1ADORA3FBP1 | |
| SCHEMBL2195761 | 0.73 | TLR7 (0.55) | TLR7TLR8 | |
| SCHEMBL23621012 | 0.71 | ADORA2A (0.50) | ADORA2AADORA2BADORA1ADORA3FBP1 | |
| SCHEMBL4903374 | 0.71 | ABL1 (0.38) | TLR7ADORA2AADORA2BADORA1ADORA3 | |
| SCHEMBL2197689 | 0.70 | TLR7 (0.46) | TLR7 | |
| SCHEMBL4298068 | 0.70 | ADORA2A (0.57) | ADORA2AADORA2BADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230322782-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2023-10-12 | — | — | US | disclosed |
| US-20230322782-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2023-10-12 | — | — | US | disclosed |
| US-11680067-B2 | Small molecules for the treatment of primary cancer and cancer metastasis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-06-20 | — | — | US | disclosed |
| US-11680067-B2 | Small molecules for the treatment of primary cancer and cancer metastasis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-06-20 | — | — | US | disclosed |
| US-20210206769-A1 | Small Molecules for the Treatment of Primary Cancer and Cancer Metastasis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2021-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11680067-B2 | Small molecules for the treatment of primary cancer and cancer metastasis | ADORA2A, ADORA3, ADORA1 | TLR7 3754/4885ADORA2A 1/4885ADORA2B 4/4885 |
| US-20230322782-A1 | SMALL MOLECULES FOR THE TREATMENT OF PRIMARY CANCER AND CANCER METASTASIS | EPCAM, MKI67, KRAS | TLR7 4706/4885ADORA2A 3164/4885ADORA2B 3679/4885 |
| US-20210206769-A1 | Small Molecules for the Treatment of Primary Cancer and Cancer Metastasis | ADORA2A, ADORA3, ADORA1 | TLR7 3754/4885ADORA2A 1/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.